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Hereditary angioedema (hae) is a rare, genetic disorder that causes episodes of swelling in the face, hands, feet and elsewhere Dawnzera (donidalorsen) became the second new hereditary angioedema (hae) therapy approved in 2025, following kalvista’s ekterly. Symptoms usually begin in childhood.

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Hae accounts for only a small fraction of all cases of angioedema Learn about hereditary angioedema (hae) symptoms, treatment options, and other things to consider when managing this condition. To avoid potentially fatal consequences such as upper airway obstruction and unnecessary abdominal surgery, the importance of a correct diagnosis cannot be overemphasized.

Hereditary angioedema is a rare genetic condition that causes swelling under the skin and lining of the gut and lungs

It can happen in different parts of your body You are born with hereditary. Our association is a community of people affected by hae and their loved ones who are leading the fight in hae research, advocacy and finding a cure. Hae symptoms include episodes of edema (swelling) in various body parts including the hands, feet, face and airway.

The most common cause of hae is a decrease in c1 esterase inhibitor (c1 inh), a protein that is part of our body’s normal immune system A peptide called bradykinin is thought to be responsible for the hae symptoms of swelling, inflammation and pain. Hae can cause painful swelling in any part of the body Common areas include the stomach, face, feet, genitals, hands, and throat

There are three types of hae

Hereditary angioedema (hae) is a rare genetic condition